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The Frontier Psychiatrists
The Curious Case of Ketamine: Is Less Often More Effective?

The Curious Case of Ketamine: Is Less Often More Effective?

New research findings in collaboration with Dr. Irfan Handoo challenge my understanding of Ketamine

Owen Scott Muir, M.D, DFAACAP's avatar
Owen Scott Muir, M.D, DFAACAP
May 07, 2025
∙ Paid
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The Frontier Psychiatrists
The Frontier Psychiatrists
The Curious Case of Ketamine: Is Less Often More Effective?
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Dr. Irfan Handoo is a brilliant physician who lives in Kansas City. He works very hard. He's dedicated to his patients' well-being to a degree might boggle the imagination of most. I've been pleased to know Irfan for several years, and we've worked together on at six publications already. I wasn't ready for my colleague upending my understanding of how IV Ketamine should be delivered.

If you want to see Dr. Handoo, here is the link:

Visit Kansas City Psychiatry Partners

Except— that's what happened.

The conversation started when Dr. Handoo told my co-author, Amna Aslam, MPH, about his data on ketamine.

Handoo’s TMS data was exciting enough: together, we had a whole series of patients who had been previously treated with ECT, and ketamine, and regular rTMS, and whose depression subsequently remitted with dTMS1— a variant of the technology using a different coil geometry, both broader and deeper than the figure-of-eight coils first demonstrated effective in 2008. We looked at our data here at Radial and found we also had…

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