This is interesting. Can you share with me a bit more about what might be going on with the chemical part across the synaptic gap when you take medication? This electrical dimension is clearly effective (TMS), as your work and that of others mentioned in your latest Substack post. As someone who was prescribed Sertraline for the first time a couple of years back, I found that for the first three months or so, maybe slightly longer, I got a boost in my energy levels and I began to do a lot of creative writing. This was very uplifting, because the drug I had been prescribed before no longer had any positive effects on my depression and it was actually getting worse. So, at first, the change was a really positive one, but after a few months the positive effects began flatlining, although I felt better than I had on the previous medication by quite some margin. I wasn’t offered a follow up appointment to see how the change from one medication to another (same dose) was going. I don’t really have time for long answers from my GP as each appointment is 10 minutes in the UK. I’m curious about the electrochemical effects that might be going on which might explain these changes.
There is a phenomenon with many medication's called tachyphylaxis, this is decreasing affect over time with the same dose. TMS does not appear to have this as part of its profile. Many medication's do you have this decreasing effect. Some of it has to do with the mechanism of action, when you increase the concentration of serotonin in a synapse, the postsynaptic cell is going to down regulate its response overtime, to maintain homeostasis. Biological systems like to maintain their stability! Stimulation like TMS is effective based on the spacing of the pulses. There needs to be a break in between if we're doing facilitator treatment that will increase activity, and there needs to be no pause between stimulations (such as the one hz stimulation described in the article) to inhibit neural firing. The downside of the lack of tachyphylaxis from TMS is that it also does not create permanent changes.
This is interesting. Can you share with me a bit more about what might be going on with the chemical part across the synaptic gap when you take medication? This electrical dimension is clearly effective (TMS), as your work and that of others mentioned in your latest Substack post. As someone who was prescribed Sertraline for the first time a couple of years back, I found that for the first three months or so, maybe slightly longer, I got a boost in my energy levels and I began to do a lot of creative writing. This was very uplifting, because the drug I had been prescribed before no longer had any positive effects on my depression and it was actually getting worse. So, at first, the change was a really positive one, but after a few months the positive effects began flatlining, although I felt better than I had on the previous medication by quite some margin. I wasn’t offered a follow up appointment to see how the change from one medication to another (same dose) was going. I don’t really have time for long answers from my GP as each appointment is 10 minutes in the UK. I’m curious about the electrochemical effects that might be going on which might explain these changes.
There is a phenomenon with many medication's called tachyphylaxis, this is decreasing affect over time with the same dose. TMS does not appear to have this as part of its profile. Many medication's do you have this decreasing effect. Some of it has to do with the mechanism of action, when you increase the concentration of serotonin in a synapse, the postsynaptic cell is going to down regulate its response overtime, to maintain homeostasis. Biological systems like to maintain their stability! Stimulation like TMS is effective based on the spacing of the pulses. There needs to be a break in between if we're doing facilitator treatment that will increase activity, and there needs to be no pause between stimulations (such as the one hz stimulation described in the article) to inhibit neural firing. The downside of the lack of tachyphylaxis from TMS is that it also does not create permanent changes.