In Praise of the Music of T-Pain

I'm as surprised as you are that this is also an article about KarXT.

It’s Saturday. I have (literally) hundreds of health-themed articles in various stages of readiness, and I don’t want to finish any of them. I do, however, want to share my newfound love for the unbelievable gift that is T-Pain's actual voice.

Yes, Faheem Rashad Najm, professionally known as “T-Pain.” The artist, songwriter, and producer who both ruined music with his wildly influential intentional misuse of Antares’ Autotune plug-in. You may know T-Pain from prior articles here, in the newsletter, like my explanation of Auvelity—a combination of dextromethorphan and bupropion for depression. We have a new combo drug out—this time, it’s the novel schizophrenia drug Cobenfy. All previous antipsychotic drugs blocked the dopamine D2-receptor. I’ve written about those drugs before in Inessential Pharmacology. (amazon link).

Cobenfy, skillfully named to suggest the combination of xanomeline and trospium is beneficial, but with an -fy ending, previously featured on Abilify, the previou…