Hold Me Closer, Robitussin: is Auvelity (dextromethorphan/bupropion) something new in depression treatment?

Basic science, deftly applied, combined old compounds to bring us the most promising oral antidepressant in 60 years.

Most of the images in this dispatch were created by artificial intelligence. This picture was made after providing the prompt to Midjourney: “A bottle of cough syrup and an antidepressant get married in a psychedelic themed wedding“

This has been a nostalgia heavy week. Not only did I get to eat at my favorite burrito restaurant from my days at Amherst College, but I got to think about Robo-tripping again. First, a moment of full disclosure:

Bueno Y Sano has the best burritos.

Sautéed spinach and garlic. The best burrito. Hands-down. It’s something about that combination—noted even on the menu, written in chalk— this remarkably simple combination of spinach and garlic as one especiale burrito. So special, in fact, that 20 years later, this is still a go-to for me!

You probably thought I was going to disclose that I did some Robo-tripping in college? You would be incorrect. I did not. This is not to say Robo-tripping wasn’t an activity of choice amongst my classmates. To quote the…